L-5MTHF 120 Capsules-High Quality Pharmaceutical


RN Labs L-5MTHF is a pure and highly bioavailable form of folate.

Directly facilitating methyl group donation in the body, L-5MTHF supports numerous metabolic processes for optimum healing, development, detoxification, mental health and wellbeing.

A study comparing the bioavailability of [6S]-5-MTHF (L-5MTHF) and folic acid (a form used in many dietary supplements) found significantly greater absorption of [6S]-5-MTHF over folic acid in healthy individuals.

This study was conducted on females profiled for genotypes with the homozygous 677C>T mutation, which was compared to individuals without this mutation.

They found an increase in plasma folate irrespective of the gene mutation, therefore, research suggests [6S]-5-MTHF is a highly absorbable form of supplementation for the general population.

Prinz-Langenohl R, Brämswig S, Tobolski O, Smulders YM, Smith DE, Finglas PM, Pietrzik K, 2009, [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C–>T polymorphism of methylenetetrahydrofolate reductase, British Journal of Pharmacology, vol. 158, no. 8, pp. 2014-2021.

Pentieva, K, McNulty, H, Reichert, R, Ward, M, Strain, JJ, McKillop, DJ, McPartlin, JM, Connolly, E, Molloy, A, Krämer, K & Scott, JM 2004, ‘The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men’, Journal of Nutrition, vol. 134, pp. 580-5.

Houghton, LA, Sherwood, KL, Pawlosky, R, Ito, S & O’Connor, DL 2006, ‘[6S]-5-methyltetrahydrofolate is at least as effectiveas folic acid in preventing a decline in blood folate concentrations during lactation’, American Journal of Clinical Nutrition, vol. 83, pp. 842-50.

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L-5MTHF 120 Capsules is a pure and highly bioavailable form of folate.Directly facilitating methyl group donation in the body, L-5MTHF supports numerous metabolic processes for optimum healing, development, detoxification, mental health and wellbeing

  • Provides a methylated and metabolically active form of folate
  • Bypasses the biochemical steps normally required by other folates
  • Demonstrates greater metabolic activity than folic acid as a source of folate, with reduced potential for side effects
  • Contributes to the normal growth of the foetus during pregnancy
  • May support normal stress and cognitive function through healthy neurotransmitter production
  • Supports healthy red blood cell formation
  • Plays an important role in supporting healthy methylation
  • Supports healthy homocysteine levels
  • Supports healthy cardiovascular and vascular endothelial function

Supplement Facts:



How would a practitioner know whether to use an active unmethylated vs a methylated folate?

Generally speaking it is best to start with folinic acid. Methyltetrahydrofolate (5-MTHF) is best utilised once a practitioner is aware of the patient’s current methylation status (i.e. via Plasma Methylation Profile and DNA Health tests).

Methylated nutrients increase SAMe, the principle methyl donor. If the body detects an excess of methyl groups, the body can down regulate the enzyme process, creating a negative feedback loop. The use of folinic acid is generally better tolerated by a greater number of individuals. Folinic will still convert to 5-MTHFR whilst allowing the body to have better regulation and control of the methylation cycle.

If supplying pre-methylated nutrients, giving them in combination with vitamin B3 would be ideal to quench any excess methyl groups that may occur.

Furthermore, taking vitamin B3 may be advantageous to support healthy overall regulation of the methylation cycle in many individuals.

Statements(L-5MTHF 120 Capsules):


If symptoms persist consult your healthcare practitioner.

Vitamin supplements should not replace a balanced diet.

Folate is considered safe during pregnancy.

Known Side Effects(L-5MTHF 120 Capsules)
In doses typically administered for therapeutic purposes, 5-MTHF is considered non-toxic. At doses over 10mg daily, gastrointestinal complaints, insomnia, irritability, and fatigue have been reported.

Whilst some concern exists that supplementation with high doses of folic acid could mask a vitamin B12 deficiency, supplementation with 5-MTHF appears to sidestep this potential problem. Since 5-MTHF can only be converted to 5,10-methylenetetrahydrofolate (involved in DNA synthesis) after participating in homocysteine recycling with vitamin B12, 5-MTHF will not mask a B12 deficiency.

Medication Interactions
The activity of 5-MTHF may affect, or be affected by, the presence of certain medications, including anticonvulsant and anti-inflammatory medications. Qualified consultation is advised when using these concomitantly.

Quality & Purity(L-5MTHF 120 Capsules):

RN Labs use only the highest grade ingredients and materials available. Our purity standards for manufacturing and sourcing are extensively researched and verified.

L-5MTHF is a pure and hypoallergenic product, developed to meet the needs of even the most sensitive patients. Formulated with no harsh or irritating excipients, ensures comfort, safety and efficacy for improved patient compliance and results.

Pure & Free From

This product does NOT contain wheat, gluten, dairy, lactose, egg, corn, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours. This product also does not contain synthetic preservatives, stearate lubricants and other commonly detrimental excipients.


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