Folinic acid subsequently appears to be a more metabolically active form of folate than folic acid, capable of supporting levels of the coenzyme forms of the vitamin in circumstances where has little to no effect.
- It readily converts to methylfolate without delivering excess external methyl groups
- It demonstrates greater metabolic activity than folic acid as a source of folate, with reduced potential for side effects
- Contributes to the normal growth of the foetus during pregnancy
- May support normal stress and cognitive function through healthy neurotransmitter production
- Supports the healthy formation and maturation of red blood cells
- Supports the synthesis and repair of DNA and normal cellular division
- Plays an important role in supporting methylation reactions
- Supports normal, healthy cardiovascular function, and improves vascular endothelial function
Why Folinic Acid over Folic Acid?
In conditions where folate is required, the potentially superior benefits of Folinic Acid supplementation as a safe, well tolerated and affordable form of folate, may often be overlooked.
It is well utilised as an immediate precursor to 5, 10-Methylenetetrahydrofolate, the step just prior to the formation of 5-methyltetrahydrofolate (5-MTHF). Oral administration of Folinic Acid therefore bypasses the deconjugation and reduction steps required for the conversion of Folic Acid to 5-MTHF.
Additionally it has been suggested that Folinic Acid might cross the blood brain barrier since reduced folates are actively transported into the brain, whereas Folic Acid on the other hand is poorly transported to the brain and rapidly cleared from the Central Nervous System.
How would a practitioner know whether to use an active unmethylated vs a methylated folate?
Generally speaking it is best to start with folinic acid. Methyltetrahydrofolate (5-MTHF) is best utilised once a practitioner is aware of the patient’s current methylation status (i.e. via Plasma Methylation Profile and DNA Health tests).
Methylated nutrients increase SAMe, the principle methyl donor. If the body detects an excess of methyl groups, the body can down regulate the enzyme process, creating a negative feedback loop. The use of folinic acid is generally better tolerated by a greater number of individuals. Folinic will still convert to 5-MTHFR whilst allowing the body to have better regulation and control of the methylation cycle.
If supplying pre-methylated nutrients, giving them in combination with vitamin B3 would be ideal to quench any excess methyl groups that may occur.
Furthermore, taking vitamin B3 may be advantageous to support healthy overall regulation of the methylation cycle in many individuals.
FOR PRACTITIONER DISPENSING ONLY.
If symptoms persist consult your healthcare practitioner.
Vitamin supplements should not replace a balanced diet.
Folate is considered safe during pregnancy.
Known Side Effects(Folinic acid)
In doses typically administered for therapeutic purposes, folinic acid is considered non-toxic. At doses over 10mg daily, gastrointestinal complaints, insomnia, irritability, and fatigue have been reported.
The activity of folinic acid may affect, or be affected by, the presence of certain medications, including anticonvulsant and anti-inflammatory medications. Qualified consultation is advised when using these concomitantly.
Quality & Purity(Folinic acid):
RN Labs use only the highest grade ingredients and materials available. Our purity standards for manufacturing and sourcing are extensively researched and verified.
Folinic Acid is a pure and hypoallergenic product, developed to meet the needs of even the most sensitive patients. Formulated with no harsh or irritating excipients, ensures comfort, safety and efficacy for improved patient compliance and results.
Pure & Free From
This product does NOT contain wheat, gluten, dairy, lactose, egg, corn, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours. This product also does not contain synthetic preservatives, stearate lubricants and other commonly detrimental excipients.