TEST BACKGROUND
There's a strong connection between using glyphosate and many long-lasting sicknesses, like autism. Other sicknesses that have a high connection with glyphosate use include high blood pressure, stroke, diabetes, being very overweight, problems with cholesterol, Alzheimer's, memory loss in old age, Parkinson's, multiple sclerosis, bowel problems, infections in the gut, serious kidney problems, different kinds of cancers like thyroid, liver, bladder, pancreas, kidney, and a type of blood cancer called myeloid leukemia. Connections don't mean one thing causes another, but they do make us worry about using a chemical that almost all living things on Earth are exposed to.

CLINICAL VALUE
Testing for glyphosate along with certain markers in the Organic Acids Test (OAT) can help figure out how much someone has been exposed to glyphosate and can help doctors plan the best treatments for patients.

KEY ASSESSMENTS
Glyphosate

BACKGROUND OF THE TEST
The GPL-Tox serves as a urine examination intended for the evaluation of toxic chemical exposure stemming from various sources including pharmaceuticals, pesticides, packaged foods, household items, and environmental pollutants.

Mosaic Diagnostics, previously known as Great Plains, has developed GPL-TOX, a comprehensive non-metal chemical profile capable of detecting 172 distinct toxic substances. Among these are organophosphate pesticides, phthalates, benzene, xylene, vinyl chloride, pyrethroid insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene oxide, acrylonitrile, and others. Additionally, this profile encompasses Tiglylglycine (TG), an indicator for mitochondrial disorders originating from mitochondrial DNA mutations. Such mutations can arise from exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.

CLINICAL SIGNIFICANCE
With the proliferation of chemical-laden products and the prevalence of toxic compounds in food, air, and water, there has been a notable surge in chronic ailments such as cancer, heart disease, chronic fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/AD(H)D, autoimmune disorders, Parkinson’s disease, Alzheimer’s disease, and more.

Mosaic Diagnostics' GPL-Tox, formerly Great Plains, holds the potential to aid healthcare professionals in pinpointing chemical exposure, thereby assisting in mitigating the associated risks linked to disease progression.

IMPORTANCE OF MOLD IGE ALLERGY TESTING

• Mold allergy denotes an anomalous immune response to mold spores or components of mold cells. Individuals may encounter mold spores or byproducts in various settings, including workplaces, residences, or outdoor environments.
• Certain professions carry a heightened risk of mold exposure, including roles in crop and dairy farming, greenhouse plant cultivation, logging, carpentry, millwork, furniture restoration, and commercial baking.
• Within residential settings, elevated mold exposure can occur in areas prone to dampness such as bathrooms, kitchens, and basements.
• Generally, inhabiting or working in buildings with moisture levels surpassing 50% humidity elevates the likelihood of mold exposure.
• Immunological responses to mold can be discerned by assessing the levels of immunoglobulin E (IgE) antibodies specific to particular mold species.
• The Great Plains Laboratory now provides an IgE blood assay capable of quantifying patient antibodies targeting the most prevalent mold species.
• These IgE antibodies are identified in blood serum using an FDA-approved enzyme-linked immunosorbent assay (ELISA).
• Common mold species associated with allergic reactions include Alternaria, Aspergillus, Cladosporium, and Penicillium. Employing both tests enables the detection of a broader spectrum of mold varieties.

IgG is a big type of antibody in our blood. It has parts called Fab and Fc. Fab helps IgG stick to bad stuff, and Fc does most of the work fighting them. Bad stuff that makes our body react is called an antigen. IgG can react to antigens in food, sometimes quickly (with IgE) or slower (with IgG).

Human IgG comes in four types: IgG1, IgG2, IgG3, and IgG4. Each type does different things in our body. IgG1 and IgG3 help protect us from getting sick again. IgG2 helps our body eat up bad stuff. IgG4 might stop our body from making too many antibodies when we are exposed to something for a long time.

Clinical Value

IgG food testing helps doctors figure out which foods might be causing problems for patients with chronic illnesses. For example, people with conditions like neurological issues, stomach problems, trouble moving, or behavior disorders often have trouble with certain foods that IgG testing can identify. Avoiding foods that show up positive in IgG tests might help improve symptoms.

Sometimes people keep eating foods that are causing them problems without realizing it. Symptoms from food issues might show up hours or even days after eating the food because IgG antibodies stick around longer than IgE antibodies. When IgG antibodies attach to food, it can cause inflammation and problems, but these reactions take time to show up.

An ear, nose, and throat doctor wrote an early article about IgG food testing. He found that many of his patients got a lot better when they stopped eating foods that tested positive for IgG allergies. This study showed that 71% of people saw at least a 75% improvement in their symptoms. The patients who benefited the most were those with long-lasting and serious symptoms that didn't get better with other treatments. Some of the symptoms that improved the most when people stopped eating certain foods were asthma, coughing, tiredness, headaches, gas, bloating, diarrhea, skin rash, itchiness, and stuffy noses. The most common IgG food allergies were to cow's milk, garlic, mustard, egg yolk, tea, and chocolate.

Another recent study found that 93% of people who were sensitive to gluten but didn't have celiac disease stopped producing a certain type of IgG antibody after they followed a gluten-free diet for six months. When these antibodies disappeared, people felt a lot better, both in their stomachs and in other parts of their bodies. High levels of IgG antibodies are often found in kids with diabetes, Crohn's disease, celiac disease, and those who are overweight.

Doctors often use IgG food test results to make diets that exclude foods causing IgG reactions. These diets have been proven to help people with gluten sensitivity, allergies, and other conditions. They can reduce migraine headaches, make diarrhea less frequent, help kids with cystic fibrosis grow better, ease symptoms of irritable bowel syndrome, improve bowel health in Crohn's disease, stop seizures and hyperactivity in kids with epilepsy, and even help kidney function in some kidney diseases. These diets also show promise in helping with attention-deficit hyperactivity disorder (ADHD).

BACKGROUND OF THE TEST

The Organic Acids Test (OAT) gives a detailed view of a person's health by looking at more than 70 markers.
This test also checks levels of vitamins and minerals, how much stress there is in the body, levels of chemicals that help the brain work, and includes markers for oxalates. Oxalates are linked to many long-term illnesses.

VALUE FOR DOCTORS

People with long-term illnesses and brain problems often have changes in the organic acids in their urine. This could be because of many things like taking antibiotics, eating too much sugar, weak immune systems, infections, or genetics. The OAT can help doctors see how well different parts of the body are working, like energy levels, thinking ability, and digestion. It's a good first test to do.

BACKGROUND INFORMATION

WHAT ARE MYCOTOXINS?
Mycotoxins are harmful substances found a lot in the environment. They're made by fungi like mold, which can grow in buildings, vehicles, and food. Most of the time, people are exposed to mycotoxins by eating contaminated food or breathing in contaminated air.

In the European Union, about 20% of the grains harvested have mycotoxins in them. Unfortunately, mycotoxins can survive even when exposed to heat or during food processing.

Fungi can grow on almost anything, especially in warm and wet places. They can grow on materials inside buildings like walls, wallpaper, insulation, ceiling tiles, and drywall. These fungi release mycotoxins into the air, which can cause many different long-lasting illnesses. Some of the illnesses and symptoms linked to mycotoxin exposure include fever, symptoms like pneumonia, heart issues, rheumatic diseases, asthma, sinus problems, memory loss, vision problems, tiredness, skin rashes, feeling sad, ADHD, anxiety, and liver damage.

WHY IT MATTERS

Mycotoxins, made by certain types of mold, are some of the most common poisons around. They're becoming a big problem for global health because they can cause serious health problems over time. It's hard to diagnose mycotoxin exposure without proper testing because the symptoms can be vague and different for each person.

The MycoTOX Profile from Mosaic Diagnostics is a very detailed test for mycotoxins. It checks levels of 11 different mycotoxins in urine, including Aflatoxin M1, Ochratoxin A, Zearalenone, and Trichothecenes. This test helps doctors find out if someone has been exposed to mycotoxins and can help plan treatment to prevent or treat problems caused by them.

BACKGROUND INFORMATION

The Organic Acids Test (OAT) is a test that gives a detailed look at a person's health. It checks over 70 different things in the body.
The OAT also looks at levels of vitamins and minerals, how much stress the body is under, levels of brain chemicals, and even measures oxalates, which are linked to many long-lasting illnesses.

WHY IT MATTERS

Many people with long-lasting illnesses and problems with their nerves might have changes in the levels of certain acids in their urine. This could be because of things like taking antibiotics by mouth, eating too much sugar, having weak immune systems, getting infections, or even because of genes. The OAT gives a broad picture of how different systems in the body are working, like how much energy the body is making, how well the brain is working, and how the digestive system is doing. So, it can be a helpful first test to take.